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X-WR-CALDESC:Events for Life Sciences PA
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DTSTART;TZID=America/New_York:20260922T160000
DTEND;TZID=America/New_York:20260922T190000
DTSTAMP:20260218T141752Z
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UID:10000260-1790092800-1790103600@lifesciencespa.org
SUMMARY:Philly Underdog Series: Session 4
DESCRIPTION:Life Science Cares is the life sciences industry’s home for giving back. In Philadelphia\, we disrupt poverty by expanding access\, meeting our community needs\, strengthening workforce pathways\, and ensuring more people have the opportunity to build careers in our region’s life sciences industry. \nA four-part convening series for Greater Philadelphia’s life sciences community. Real conversation\, real connection\, and a clear link to local impact through Life Science Cares Philadelphia. \nSession 1 is sold out. Join the waitlist to be first in line if seats open and to receive priority updates for future sessions. \n			\n				Click Here to Register
URL:https://lifesciencespa.org/event/philly-underdog-series-session-4/
LOCATION:Cira Center\, 2929 Arch Street\, Philadelphia\, 19104
CATEGORIES:Supported Events
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DTSTART;TZID=America/New_York:20260922T170000
DTEND;TZID=America/New_York:20260922T190000
DTSTAMP:20260903T144629Z
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UID:10000350-1790096400-1790103600@lifesciencespa.org
SUMMARY:Corporate Innovation & Entrepreneurship Fall Social
DESCRIPTION:Celebrate the Fall season with a evening hosted by Dentons! Join us for a networking event among the city’s innovation and entrepreneurship community. \nEnjoy light hors d’oeuvres\, drinks\, and engaging conversations as we gather to reconnect with old friends\, forge new connections\, and immerse ourselves in the dynamic spirit of innovation\, entrepreneurship\, and technology. \nWeather permitting\, we’ll experience the heart of the city from our fifth-floor rooftop terrace. Come enjoy all the sights\, sounds\, and energy that come with it! \nWe look forward to having you join us! \n			\n				Click Here to Register
URL:https://lifesciencespa.org/event/corporate-innovation-entrepreneurship-fall-social/
LOCATION:Dentons Cohen & Grigsby P.C.\, 625 Liberty Avenue - 5th Floor\, Pittsburgh\, PA\, 15222
CATEGORIES:Supported Events
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DTSTART;TZID=America/New_York:20260922T173000
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DTSTAMP:20260916T123415Z
CREATED:20260916T123406Z
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UID:10000354-1790098200-1790098200@lifesciencespa.org
SUMMARY:Mapping Spatial Energy Metabolism in Tumors Using MALDI Imaging Mass Spectrometry
DESCRIPTION:Please RSVP to dvmsdg2@gmail.com for parking information.  \nAbstract: \nTumors have altered metabolism\, in particular high glycolytic flux (Warburg metabolism). Altered tumor metabolism can be used to enable tumor identification and is also correlated with tumor progression and metastasis. However\, it is not known whether metabolism varies spatially within tumors\, and whether such variation affects tumor growth. We developed an approach to measure glycolysis flux with high spatial resolution (down to 10 μm2) by combining IV infusion of 2-deoxyglucose with MALDI imaging mass spectrometry of mouse tumors. We found that pancreatic tumors exhibit glycolysis-high and -low zones\, with a four-fold difference in glycolysis flux between regions. In contrast\, the other energy-producing pathway\, the TCA cycle\, was uniform across the tumor. We found that glycolysis flux was upregulated in poorly perfused tumor regions. Acute treatment with a KRAS inhibitor\, recently approved to treat pancreatic cancer\, strongly reduced tumor glycolysis in most but not all tumor cells. In future\, we will test whether cells with high glycolysis in the presence of drug give rise to drug resistance. Overall\, we present a platform to combine tracer infusion and MALDI imaging mass spectrometry to measure spatial metabolism in tissues and tumors.
URL:https://lifesciencespa.org/event/mapping-spatial-energy-metabolism-in-tumors-using-maldi-imaging-mass-spectrometry/
LOCATION:LSPA Headquarters\, 411 Swedeland Rd\, King of Prussia\, PA\, 19406\, United States
CATEGORIES:Supported Events
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